Sentence examples for by suppressing the function of from inspiring English sources
IFN-γ repressed genes by suppressing the function of enhancers enriched for binding by transcription factor MAF. Mechanistically, IFN-γ disassembled a subset of enhancers by inducing coordinate suppression of binding by MAF, lineage-determining transcription factors, and chromatin accessibility.
Our observations on the repressive function of Math6 on some Neurog3-targeting events is consistent with the activity of its Drosophila orthologue net which prevents wing vein formation by suppressing the function of vein-promoting genes [31].
Previous research indicated silkworm cells are suspended in G2 at DS [68], [69], and Ser/Thr protein phosphatase, targeted by bmo-miR-iab-4-3p, controls the transition of G2 to M [70], suggesting that bmo-miR-iab-4-3p may play a pivotal role in keeping embryonic cells at G2 by suppressing the function of Ser/Thr protein phosphatase.
Several studies have shown that imatinib can reverse MDR by suppressing the function of certain ABC transporters.
It has recently been shown that during development, FADD and caspase-8 promote survival by suppressing the function of RIPK1- and RIPK3-mediated necroptosis.
Treg, characterised by the expression of surface antigens CD4 and CD25 and the transcription factor forkhead box P3 (FOXP3), control inflammation by suppressing the function of Teff.
Attack by the immune system suppresses the function of the β cells and can cause them to undergo a form of programmed cell death called apoptosis.
Therefore, ectopic Runx2 elicits a lactation defect by inhibiting terminal differentiation possibly by suppressing the normal function of the PRLR pathway.
In addition, it was reported that doxorubicin and echinomycin suppress the function of HIF-1 by inhibiting HIF-1′s binding to HRE [ 107, 111].
FOXP3+ Treg cells are known to disrupt anti-tumour immunity by suppressing the effector functions of various immune cells and have been implicated in escape of cancer cells from immunosurveillance (Ding and Zhou, 2012).
