In this study, we demonstrate that Nrf2 represses antiviral cytosolic sensing by suppressing the expression of the adaptor protein STING.
Duan, L. et al. KDM4/JMJD2 histone demethylase inhibitors block prostate tumor growth by suppressing the expression of AR and BMYB-regulated genes.
Glycine-rich RNA-binding proteins 7 and 8 show robust circadian oscillations of protein levels, forming the negative arm and promoting flowering by suppressing the expression of the FLC protein under noninductive conditions41,42.
This suggests that, in sweet sorghum, the degradation of hemicellulose is promoted by suppressing the expression of xylanases inhibitors.
Our data show that rapamycin significantly reduced glycogen content in primary muscle cells from human patients with GSD IIIa by suppressing the expression of glycogen synthase and glucose transporter 1.
We present the evidence that TCR antagonism renders agonist-activated T cells susceptible to bystander CD95-mediated killing by suppressing the expression of cellular Fas-associated death domain-like interleukin-1beta-converting enzyme-like inhibitor proteins.
Sudachitin had been found to inhibit NO production by suppressing the expression of iNOs in LPS-stimulated macrophages, to exhibit anti-inflammatory activity, and was a more potent anti-inflammatory agent than nobiletin [67].
For example, Sub1A-1 inhibits leaf elongation by suppressing the expression of expansin-encoding genes and restrains carbohydrate consumption by reducing the expression of α-amylose genes and sucrose synthase genes [39].
AtOFP1 was shown to regulate cell elongation by suppressing the expression of Gibberellin 20 oxidase 1 (Ga20ox1), a gene encoding the key enzyme in gibberellin (GA) biosynthesis (Wang et al. 2007).
They are characterized in facilitating virus propagation and pathogenesis by suppressing the expression of viral or cellular genes [16], [18].
It is interesting that deletion of IKKβ in microglia reduces neurodegeneration in a chemical model of HD by suppressing the expression of pro-inflammatory cytokines [41].
