Autophagy has also been shown to be initiated by chemical inhibition of IP3Rs or suppressing its expression thereby suppressing the Ca2+ signaling.
Finally, we genetically silenced ERβ expression using ERβ siRNA in T47D cells, which suppressed its expression by 60% (Supplementary Figure S2C).
At the molecular level, miRNA binds to 3′-untranslated 3′-untranslated of taregionRNA(s) and suppresses its expression by either translational repression or mRNA cleavage [ 10].
In this study, we show that ibuprofen is a potent inhibitor of Hsp70, which significantly suppresses its expression by depleting heat shock factor 1 (HSF1) in lung adenocarcinoma-derived A549 cells.
To test the contribution of Lck, the major Src kinase in T cells, in the regulation of signaling dynamics, we suppressed its expression by RNAi in Jurkat T cells and evaluated the effects on Erk activation.
In some cases fusion of a gene may suppress its expression, perhaps by destabilising the mRNA: among the predicted fusion genes for which we could not detect a transcript, unfused copies of some of the 5' participating genes were transcribed for example SSH2, NUDCD1 and TRAPPC9 (Table 1; Additional file 7).
Blimp1 deficiency attenuates downregulation of IRF-8, MafB and Bcl6 expression after RANKL stimulation, and thus Blimp1 promotes osteoclast differentiation by suppressing expression of its repressors.
Other interactions besides being a possible substrate or inhibitor seem to exist, since imatinib itself could attenuate its resistance by suppressing BCRP expression (Nakanishi et al, 2006).
A similar complex interaction between BCRP and imatinib has been described by Nakanishi et al (2006) who showed that imatinib itself could attenuate its resistance by suppressing BCRP expression.
