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A PRNP codon 129 valine expressing counterpart was engineered by suppressing expression of endogenous PRNP codon 129MM expression with RNAi and transient transfection with a PRNP codon 129 valine expression vector (designated 129V).
We demonstrated that over-expressions of OsIDS1 and SNB inhibited flowering time in rice by suppressing expression of Ehd1.
In particular, 4a induced apoptosis in HT29 cells by suppressing expression of Bcl-2 and Bcl-XL, which preliminary explained the mechanism origin of antitumor effect.
DHA coupled with cisplatin (CDDP) has been shown to exhibit anti-angiogenic effect by suppressing expression of the vascularization-related proteins HIF-1α and VEGF both in vivo and in vitro [119].
Taken together, oleate induces chicken adipocyte differentiation, at least in part, by suppressing expression of GATA2.
These results suggest that HER2Δ16 employs a novel mechanism of tamoxifen resistance by suppressing expression of BCL-2 regulating miRNAs.
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Overexpression of miR-133b inhibits cell metastasis in vitro and in vivo partly by directly suppressing expression of Gli1 protein.
Moreover, TLRs cooperate with IFN-γ to inhibit osteoclastogenesis by synergistically suppressing expression of RANK and c-Fms [ 17].
More specifically, ligand-activated ERα suppressed expression of slug by direct repression of transcription.
In the present study, we demonstrated that E2 significantly induced bcl-2, cyclin D1 and survivin expression by suppressing the expression of a set of miRNAs in ERα dependent manner in MCF-7 cells.
We and others found that miR-200 regulates the epithelial-to-mesenchymal transition (EMT) by suppressing the expression of mesenchymal genes and inducing expression of epithelial genes [ 5- 8].
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by suppressing activation of
by suppressing invasion of
by suppressing secretion of
by suppressing senescence of
by suppressing activity of
by suppressing phosphorylation of
by suppressing growth of
by suppressing synthesis of
by suppressing proliferation of
by suppressing removal of
by suppressing criticism of
by suppressing execution of
by suppressing formation of
by suppressing pulverization of
by suppressing elongation of
by suppressing generation of
by suppressing transcription of
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