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Both daf-18 and the aak genes appear to regulate germline quiescence by suppressing activity of TORC1.
p16 promotes cell cycle arrest in response to DNA damage by suppressing activity of CDKs, such as CDK4 and CDK6 (Sherr and McCormick 2002).
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These include the regulation of cell motility and differentiation by controlling the activity of ROK-α and the regulation of apoptosis by suppressing the activity of the proapoptotic kinases ASK1 and MST2, none of which requires Raf-1 kinase activity (reviewed in [ 45- 47]).
Alternative inhibitory result was also reported later for hepatitis B virus (HBV) that 911 drug could inhibit the virus replication by suppressing the activity of DNA polymerase activity [ 58].
We previously showed that SRSF1 promotes translation initiation of bound mRNAs by suppressing the activity of 4E-BP, a competitive inhibitor of cap-dependent translation.
We have previously shown that SRSF1 promotes translation initiation of bound mRNAs by suppressing the activity of 4E-BP, a competitive inhibitor of cap-dependent translation.
Furthermore, we also uncovered the molecular mechanism by which SRSF1 promotes translation by showing that it promotes translation initiation of bound mRNAs by suppressing the activity of 4E-BP, a competitive inhibitor of cap-dependent translation.
Glucocorticoids elevate cellular cAMP levels by regulating the activity of both adenylyl cyclases and phosphodiesterases, predominantly by suppressing the activity of phosphodiesterases [ 19, 20].
It has been suggested that the phosphorylation of NDRG1 inhibits the malignant progression of cancer by suppressing the activity of the NF-κB (nuclear factor-κB) signalling pathway, thereby reducing the expression of angiogenic CXC chemokines [ 16].
Rok can contribute to myosin II RLC phosphorylation in two ways: through the phosphorylation of the RLC and by suppressing the activity of the myosin phosphatase by phosphorylation of its subunit Mbs [10].
Mesp2 also induced the expression of Ripply 1 and 2, which in turn played roles in restricting the expression domain of Mesp2 by suppressing the activity of Tbx6.
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