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This material opens an avenue for the preparation of new functional materials by conversion of the nitrile group into amines, carboxylic acids, amino acids and chiral groups, according to the desired application, by subtle modifications in the synthetic methodology.
These fundamental differences in enzymatic activity do not arise from changes in the catalytic mechanism but rather are determined by subtle modifications in the primary sequence and structure of these proteins.
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Our findings indicate that subtle modifications in the peptide moiety of lipopeptides have a great impact on the immunomodulatory properties of these molecules.
Subtle modifications in the equilibrium of NP flora could lead to different etiological profiles of AOM and eventually other respiratory tract infections.
Now a team reports that one serious side effect can be overcome by a subtle modification in the amino acid sequence of the promising drug.
The action of antifungal agents is modulated by subtle modification of the membrane lipid composition [17].
This quality can be changed by very subtle modifications and needs to be considered in the interpretation of studies.
The reason is obvious low-decomposition depth causes the hash string tobvious low-decomposition low frequency coefficient depthwhile differencausesused by subthe image modifications are found in hasher frequency coefficient data.
In the same way, the analysis of subtle modifications of biomolecule content in the blood vessels (BVs) could reveal tumour growth in different stages [ 14].
The results will benefit the design of band structures, especially subtle modifications by selecting suitable wall undulations.
The preliminary results showed that subtle modifications of rhamnosyl moiety in anthracene rhamnosides with acetyl group had a selective toxicity for different tumor cells and the displacement of C-10 carbonyl group in emodin by acetylmethylene group was helpful to improve the inhibitory activity.
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