Sentence examples for by substantial changes in from inspiring English sources

In general, outliers were created by substantial changes in the stream behavior.

Aging is characterized by substantial changes in sleep architecture altering memory consolidation.

The results demonstrate that the electrochemical reduction of titanium dioxide to titanium metal is accompanied by substantial changes in the microstructure.

For certain values of the physical parameters frequency coalescence or the so-called phenomenon of frequency avoidance is observed, accompanied by substantial changes in the mode shapes.

Overall, while enrichment and depletion of cholesterol moderates insulin release from BRIN-BD11 cells, endosomal cholesterol trafficking protein StarD3 does not appear to be regulated by substantial changes in sterol metabolism in BRIN-BD11 cells.

Recent advances in paleoneurology and developmental biology show that this major transformation is reflected by substantial changes in the head region of early euarthropods, as informed by the segmental affinity of the cephalic appendages [1, 4 6].

Some mantle convection models constrained by reconstructed time-dependent plate motions suggest that the supercontinent formation and breakup was accompanied by substantial change in mantle convection pattern (Zhang and Zhong 2011; Zhang et al. 2010; Zhong et al. 2007).

We hypothesized that major changes in staffing would in most cases have been accompanied by substantial changes also in work organization and work environment, although this need not always have been the case.

Our model also posits that the elicited by LCA substantial changes in mitochondrial membrane lipidome and the resulting major changes in mitochondrial morphology act in synergy to alter the age-related chronology of mitochondrial respiration, electrochemical membrane potential, ATP synthesis and ROS homeostasis.

Analysis of the gels by densitometry revealed substantial changes in protein expression in some of the protein spots we analyzed.

Also, for HbA1c, interactions by study drug treatment were not significant in subgroups of patients categorised by baseline levels of BMI, median baseline levels of HbA1c, total daily insulin dose, or by evidence of substantial changes in the insulin regimen during the trial (data not shown).