Sentence examples for by studying the binding from inspiring English sources

Computer-aided drug design (CADD) tools added a benefit to the design and development of new CDK inhibitors by studying the binding pattern of the inhibitors to the ATP binding domain of CDKs.

The present study focused on the latter aspect by studying the binding of the wild-type and the truncated αA-crystallins with the putative target proteins.

In addition, by studying the binding to Diva of Harakiri constructs of different length we identify the critical region for binding in Harakiri and observe that affinity increases for constructs longer than this region, suggesting that the flanking sequence can influence binding.

The mechanism by which α-ketoglutarate regulates the ability of PII to control its receptors was examined by studying the binding of PII to its receptors and by measuring the effect of α-ketoglutarate on the extent of receptor activation and the concentration of PII required for activation (PII Kact).

Indeed, this agrees with a recent hypothesis proposed by Kanno et al. that TBC domain proteins do not directly interact with Rabs, but depend on other protein-protein interaction domains, such as ankyrin repeats; this was shown by studying the binding of truncation mutants for a protein containing both a Rab-GAP and a C-terminal ANK domain [ 33].

This hypothesis was then examined by studying the bindings of these peptides with their receptors in mammals and conflicting results were reported.

Transcriptional enhancers have been generally identified by studying the genome-wide binding of the acetyl-transferase P300, a ubiquitous enhancer co-activator [ 1, 6, 7].

Two research groups recently utilized such in silico techniques by employing 3D molecular docking to study the binding mode abacavir with HLA-B*57 01 HLA-B*57 01zepine with HLand*15:02.

Similar results were recently obtained by another group studying the RNA binding protein TDP-43 [ 36].

As a means to address the conflicting data about the significance of NRE for TSHβ down-regulation by T3, we studied the TR binding affinity for the NRE present in the TSHβ promoter.

As shown by these studies, the binding interfaces of both strains are located in the same region of the outermost P2 domain, but the positions and amino acid composition of individual binding sites and the HBGA binding modes are different.