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The appropriate duration of persistence is normally achieved by structural modifications that improve stability in light without compromising biodegradability.
The functional attributes of the phase, such as duration, male gametophyte competition and regulation of the number of pollen tubes (selection/screening), are controlled by structural modifications that have accompanied the closure of carpels (angiospermy) in flowering plants (Bell 1995; Herrero and Hormaza 1996; Sage et al. 2009; Williams et al. 2010).
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This knowledge could drive the lead optimization process by suggesting structural modifications that might be beneficial for the primary activity, while decreasing any undesired off-target interactions.
Members of Scabioseae have five petals while the Dipknautids (and Bassecoia) have four, and the epicalyx in Scabioseae is characterized by several structural modifications that are not present in Bassecoia or in the Dipknautids [ 34].
The binding affinity could be affected by chemical or structural modifications that alter the global mAb properties rather than those only located on the Fc region.
Continuous SAR regions are characterized by the presence of compounds with structural modifications that lead to gradual changes in potency, whereas discontinuous SAR regions contain structural analogs with large (and essentially unpredictable) potency variations.
The combination can reveal intrinsic protein structural modifications that cannot be analyzed by SPR detection alone.
The results suggest that HAMLET is recognized by the 20S proteasomes but resists degradation and forces the proteasomes to undergo structural modifications that inhibit their activity.
Previous studies have shown that enzymatic cleavage of heparin sulfate by heparinase results in disassembly of the extracellular matrix and basement membrane dissolution, inducing structural modifications that loosen the extracellular matrix barrier and enable cell invasion [ 51].
During the S-phase, chromatin undergoes major structural modifications that are inherent to DNA replication [32].
Structural modifications that reduce the absorbance properties of the dye affect subsequent fluorescence properties.
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