Sentence examples for by structural modification of from inspiring English sources

Imidacloprid is obtained by structural modification of the lead compound CH-IMI [1 3].

Therefore, we tried to find non-hypotensive antagonists by structural modification of such compounds.

Pyrroloazepinones 8a j and 9a j were designed by structural modification of lead compound 3.

A novel series of imidazolidinone-based matrix metalloproteinase (MMP) inhibitors was discovered by structural modification of pyrrolidinone 1a.

Indolones 4 and 5, and indolyl-aminoacids 6a e, 7a e, and 8a and 8b were designed by structural modification of lead compound 3.

To discover novel natural-product-based pesticidal agents, a series of honokiol/magnolol azo derivatives were prepared by structural modification of honokiol or magnolol.

It is therefore likely that the reduced CB immunoreactivity is caused by structural modifications of the CB Ca2+-binding site or misfolding of the protein itself [ 11, 50].

A series of new anti-cancer pyrimidine acyclonucleoside-like compounds were designed and synthesized by structural modifications of 5-fluorouracil, a drug which causes considerable cell toxicity and morbidity, and we evaluated their applicability for differentiation therapy in human rhabdomyosarcoma cells.

A gap in the spectrum of monolayer graphene can be induced by controlled structural modification of the graphene channel [14], by interaction of the sample with the substrate [15] and by patterning it into nanoribbons [16].

Furthermore, since complex genomic and nongenomic pathways appear to be involved in the action of 1,25(OH)2D3, separation of these effects by structural modification might be feasible.

A series of novel hedgehog signaling pathway inhibitors have been designed by structural modification based on the former reported scaffold of 4- 2-pyrimidinylamino benzamide.