This apparent disequilibrium can be readily achieved in aneuploid cells, e.g. by the structural instability of polysomic chromosomes, with breakage within late replicating regions of supernumerary chr3, often close to the centromere [ 6].
Seismic collapse is usually triggered by structural instability or the P-delta phenomenon, preceded by the formation of partial or complete ductile failure mechanisms.
Thus, analysis of the catalytic properties of the quadruple-mutant enzyme would not be expected to be influenced by structural instability during the assays.
The observation of readily detectable levels of apocytochrome of the F15A and F15E variants in cytoplasmic extracts suggests that the lack of heme attachment to these two variants is caused by loss of recognition by HCCS, rather than structural instability of the proteins in either the apo or holo forms.
Although the mechanisms are poorly understood, aggregation is thought to be favored by local abundance, modification, and structural instability of vulnerable proteins (Wright et al., 2005; Liachko et al., 2010; Dillin & Cohen, 2011) and opposed by chaperones, ubiquitin proteasomal clearance, and autophagy (Bennett et al., 2007; Jia et al., 2007).
The forces carried in all six struts decreased and confirmed the structural instability of the OT structure.
Duchenne muscular dystrophy is caused by dystrophin mutations that lead to structural instability of the sarcolemma membrane, myofiber degeneration/regeneration and progressive muscle wasting.
Mutations of two buried residues outside the catalytic center, I16T and A28P (Fig. 4A) found in some radiosensitive immune deficient patients [136,140], are predicted by SDM analysis [141] to result in structural instability of the β-Lact domain.
However, the implementations are still thwarted by dramatic capacity decay caused by the dissolution of lithium polysulfides, the low conductivity and the structural instability of the sulfur cathode originated from the volumetric changes during the charging/discharging process.
The underlying idea is that the structural instability of the cubic phase is typically indicated by van Hove singularities 26 in proximity of the Fermi energy (EF) resulting in high peaks of the density of states (DOS).
