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As for base-pair changes, knowledge of gene and genome function has been informed by structural alterations that convey clinical phenotypes.
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Often, tissue structure is observed by histology and electron microscopy, but the structural alterations that may have occurred are not always evident.
The trimeric MEC-4 model provides insight into the mechanism by which gain-of-function mutations cause structural alterations that result in increased channel permeability, which trigger cell degeneration.
Importantly, as the activation gate I205 is on the N-terminus of helix S3a, ATP binding may cause structural alterations that affect the gate, leading to channel opening.
Taken together, these studies revealed structural alterations that could be related to changes in mechanical properties.
In acute liver damage, LSEC suffer structural alterations that can promote inflammation.
Spinal cord (SC) injury causes structural alterations that result in permanent sequels to the nervous system.
Some of these studies have also demonstrated that pulmonary hypertension was associated with functional alterations and PA structural alterations, that is, vascular remodeling [ 12].
This might be part of the structural alteration that is sensed by EBs.
It can be affected by structural alterations caused by sleep bruxism.
Apoptosis was originally defined by structural alterations in cells observable by transmitted light and electron microscopy.
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