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The interaction between age and genotype was further investigated by stratifying the analysis according to the median age of 65.
Effect modification was evaluated by stratifying the analysis and testing homogeneity of RRs between groups using Mantel-Haenszel method.
Consequently, bottled water use was examined by stratifying the analysis on whether women ever regularly used bottled water.
We also explored whether there were any sex-specific associations by stratifying the analysis based on sex of the offspring (Supplementary Material, Table S3).
However, by stratifying the analysis by whether the data were missing for medical reasons using a pattern mixture model, we mitigated the effects of data MNAR.
Finally, we specifically tested the hypothesis that the intervention could have had a differential effect among those with or without alcohol dependency by stratifying the analysis on three levels of CAGE scores.
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We explored this apparent discrepancy by stratifying the fitness analysis of T242N according to CD4 count (Figure 5b), and found that in patients with advanced disease (CD4 counts <100 cells/µl), viral fitness had been restored even though the T242N persisted (p = 0.0028).
This confirms the importance of stratifying the analysis by SES levels.
In addition, we found important differences when stratifying the analysis by income groups.
Cohen's d effect size also remained lower than 0.3 for the total sample when stratifying the analysis by gender.
The result was statistically significant, in both women and men, when stratifying the analysis by sex (data not shown).
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