Furthermore, p300 alone did not stimulate DNA binding by WRN488 1432, but acetylation of WRN488 1432 stimulated its DNA binding activity (Fig. 7B).
Deacetylation of FoxO1 by Sirt1 was shown to stimulate its DNA binding, and transcriptional activity [2], [29], [36].
Interleukin-6 is an inflammatory cytokine [ 5], whose synthesis is stimulated by its binding to IL6R.
Work over the last decades revealed that Ca2+ binding to synaptotagmin triggers release by stimulating synaptotagmin binding to a core fusion machinery composed of SNARE and SM proteins that mediates membrane fusion during exocytosis.
Therefore we propose that EphrinB2 signaling would promote epithelialization in two complementary ways: (1) by lowering the activity of Cdc42 promoting epithelialization [69] and (2) by stimulating the binding of caudal s0 cells to the FN matrix which, in turn, induces N-cadherin polarization, cell elongation and centripetal alignment.
TNF α via NF κB signaling stimulates aromatase expression through CYP19A1 (aromatase) promoter I.4 by stimulating the binding of c-Fos and c-Jun transcription factors to the activation protein-1 (AP-1) element upstream of promoter I.4, while PGE2 stimulates aromatase expression through promoter II/I.3 of the human CYP19A1 gene [ 13].
Another representative example is the module (7 members) characterized by the eIF3 (7 members) complex, which is responsible among with other eIFs for the initiation of protein synthesis in eukaryotic cells by stimulating the binding of mRNA and methionyl-initiator tRNA (tRNAi-Met) to 40S ribosomes to form the 48S pre-initiation complex [ 48].
CXCR4 is known to promote cell adhesion by stimulating binding of integrins, such as α4β1 and αLβ2, to their respective ligands [39].
TBI induces the expression of GADD34 by stimulating binding of a stress inducible transcription factor, ATF4, to the GADD34 promoter.
