Sentence examples for by stimulating expression of from inspiring English sources

Type I interferons (IFNs) are expressed by all nucleated cells in response to viral pathogens and modulate innate and adaptive immune responses by stimulating expression of subsets of interferon stimulated genes (ISGs).

Adrenergic stimulation and cold stress in rodents increase energy expenditure by stimulating expression of Ucp1 in the interscapular BAT depot during the recruitment of BAT in this depot [ 21] and by the appearance of brown adipocytes in white adipose tissue (WAT) [ 8, 22, 23].

The constitutively activated SDF-1/CXCR4 axis has been shown to play a crucial role in promoting tumor growth through paracrine and/or autocrine stimulation of tumor cells, promoting tumor invasion and metastasis by stimulating expression of MMPs, and trafficking tumor cells to target organs or tissues along ligand gradients.

Import of UA into XOR deficient cancer cells may further promote proliferation and survival in part by stimulating expression of COX-2.

In summary, we identify protein acetylation as a novel mechanism underlying regulation of TFEB transcriptional activity for the first time, and demonstrate that deacetylation of TFEB in microglia enhances lysosomal biogenesis by stimulating expression of its target genes, which ultimately facilitates fAβ degradation and decreased amyloid plaque deposition.

Topological changes might also rescue cell growth by stimulating expression of genes involved in the stabilisation, repair or restart of altered replication fork [56], [57].

The ciliary phenotypes of Cby−/− mice and high expression of Cby in ciliated cells are reminiscent of those associated with the master ciliogenesis transcription factor Foxj1. Foxj1 is expressed in respiratory ciliated cells, and drives the motile ciliogenesis program by directly stimulating expression of various ciliogenesis genes including dyneins [31], [32], [33], [34].

In human macrophages and respiratory epithelial cells, vitamin D plays a role in innate immune responses by increasing TLR coreceptor, CD14, and stimulating expression of antimicrobial peptides, such as cathelicidin during respiratory infection [ 35, 36].

The future development of strictly selective inhibitors of HIF-degrading prolyl-hydroxylases therefore seems worthwhile, since stabilization of HIF may be of potential therapeutic value at least for cartilage repair approaches by supporting chondrogenic differentiation (for example, via stimulating expression of SOX9).

In contrast, myostatin has opposite effects and is considered a negative regulator of muscle growth [ 25– 27] by reducing Akt/mTOR signalling [ 28, 29] and stimulating expression of MAFbx and MuRF-1 [ 27].

It is therefore possible that stimulating expression of SUR2A over the levels of Kir6.2 expression would suppress the functional expression of KATP channels from optimized dimeric SUR2A/Kir6.2.