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83, 84 Viral RNA and polyI C affect the promotion of tissue recovery by stem cell activation.
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Satellite stem cell activation is the process by which quiescent precursor cells resident on muscle fibers are recruited to cycle and move.
Disruption of the tissue-specific epithelial stem cell niche by the fibrotic ECM may further result in aberrant stem cell activation and/or stem cell loss.
As c-Met is highly expressed by various stem cell populations, this might suggest a role in stem cell activation (Chmielowiec et al., 2007).
Prior research by Festa et al has shown that adipocytes are needed to push follicular stem cell activation.
This process can be understood as stem cell activation.
Not only the timing of stem cell activation but also the subsequent long-term contribution to the re-epithelialised wound area vary between different populations of stem cells (reviewed by Plikus et al., 2012).
Whereas superficial wounds are readily healed by relatively simple processes, full-thickness wounds provide a means to study numerous aspects of regeneration, including stem cell activation.
In mesenchymal stem cells, activation of Wnt signaling leads to cellular senescence by a pathway that includes activated p53 plus DNA damage responses [ 27].
In contrast, Erk activation induced by stem cell factor, which activates c-Kit in the same cells, is sensitive to Raf inhibition and insensitive to PI3K and PKC inhibitors.
Using patch clamp recording we have been unable to identify any Kir-like currents in HLMC (manuscript submitted), but as mast cells require activation by stem cell factor for survival and Kir 2.0 channels may be closed by tyrosine phosphorylation [ 11], it is possible that the channels are closed under basal conditions.
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