Sentence examples for by standard disproportionality analysis from inspiring English sources
This allows it to highlight emerging safety signals not detected by standard disproportionality analysis: while the global IC025 is negative, there is disproportional reporting (IC005 > 0) for the age groups 12 17 years and 18 44 years.
To study its performance relative to standard disproportionality analysis, vigiRank was compared with the IC (see Sect. 2.1.2).
Improving the performance of disproportionality analysis methods by increasing the signal-to-noise ratio would thus be important.
By design, vigiRank is less likely than basic disproportionality analysis to highlight report series with as few as three reports.
Disproportionality analysis was performed by calculating the reporting odds ratio (ROR), with the corresponding 95%% confidence interval (CI).
PK/PD parameters were computed by standard non-compartmental analysis.
See Methods section for details Table 2 provides the results of disproportionality analysis (crude ROR) obtained by combining groups through a progressive cumulative approach (1+2+3+4).
We investigated the potential CRPS signal in relation to HPV-16/18-adjuvanted HPV-16/18-adjuvanted HPV-16/18-adjuvanted CRPS cases with independent expert confirmation; a disproportionality analysis and analyses of temporality; an observaccinesus expeCervarix®ysis using pubyishedatabaseound incidence review systematic reviews of aggregate safety data, and a literature review.
However, the implications of including concomitant medications in disproportionality analysis, which is not able to deal with confounding by co-medication, are beyond the scope of this paper.
Second, we applied the case/ noncase disproportionality analysis to the four groups of events; cases were represented by reports of arrhythmias according to PTs of MedDRA® coding, whereas noncases were defined as all other reports (i.e., those without such PTs).
