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By stabilizing the cell membranes and decreasing the production of pro-inflammatory and vasoactive substances, GCs reduce microvascular permeability.
It was reported that milk promotes survival at low temperature by stabilizing the cell membrane constituents and forming a protective coating on the cell wall proteins (see review [ 27]).
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With the process described above, D-α-tocopherol is involved in stabilizing the cell membrane by inhibiting oxidation of polyunsaturated fatty acids, such as arachidonic acid of membrane phospholipids.
Ang1 appears to be able to prevent this process presumably by stabilizing the pericyte-endothelial cell association.
It is clear that paclitaxel/docetaxel induce cell apoptosis by stabilizing the microtubule spindle, arresting the cell at M phase.
NSun2 is a nucleolar protein that is regulated by Aurora B kinase and promotes cell division by stabilizing the mitotic spindle in cancer cell lines, yet this function seems independent of its methyltransferase activity and has yet to be confirmed in vivo [ 30,31].
This is achieved by stabilizing the adhesion between T cells and APCs (association of CD4 and MHC II/peptide complex) and enhancing signal transduction of the TCR/CD3 complex [ 15, 16].
Moreover, according to recent reports, a CD44 variant suppresses the accumulation of reactive oxygen species in gastric cancer cells by stabilizing the glutamate-cystine transporter and controlling the intracellular level of glutathione 14.
Rho-associated kinase (ROCK) is likely to enhance the metastatic propensity of breast cancer cells by stabilizing the actin cytoskeleton, enhancing actin-myosin contraction and promoting the c-myc pathway, including transcription of c-myc regulated miRNAs.
Intracellular Hsp70 with other heat shock proteins play an essential role as molecular chaperones by assisting the correct folding of nascent and stress-accumulated misfolded proteins, whereas extracellular Hsp70 is thought to be internalized via scavenger receptors to promote cell survival by stabilizing the membranes of lysosomes [71], [72], [73].
Zhangfei suppresses the UPR and cell growth by stabilizing the tumour suppressor protein p53 [ 6].
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