Sentence examples for by stabilizing the binding from inspiring English sources

Leucovorin (formyltetrahydrofolate, formyl-FH4) increases fluorouracil by stabilizing the binding of fluorodeoxyuridine monophosphate to thymidylate synthetase.

We confirm that zebularine exerts its demethylation activity by stabilizing the binding of DNMTs to DNA, hindering the methylation and decreasing the dissociation, thereby trapping the enzyme and preventing turnover even at other sites.

Recent analyses have suggested that MLL-AF4 promotes transcription elongation by stabilizing the binding of factors such as pTEFb, DOT1L, ELL, AFF4, AF9, and ENL at target genes in vivo (Lin et al., 2010; Yokoyama et al., 2010).

Oct-1 might activate the epithelial- specific HPV16 enhancer by stabilizing the binding of a nuclear factor to the composite element, which in turn results in higher levels of enhancer activity[ 33].

These results suggest annotation of the CTDUF as an ALDH superfamily domain that facilitates P5CDH activity and substrate channeling by stabilizing the aldehyde-binding site and sealing the substrate-channeling tunnel from the bulk medium.

Therefore, lowering the intracellular Ca2+ levels by inhibition, the VGCC AMPAR PKC signaling pathway (Fig.  9) during the progress of PCD will beneficially modulate Ca2+ homeostasis by stabilizing the Ca2+-binding capability of CB and prevent the induction of the critical calpain response cascade.

Furthermore, the hairpin facilitates P5CDH activity and substrate channeling by stabilizing the aldehyde substrate-binding loop and sealing the substrate-channeling tunnel from the bulk medium.

Unlike the −35 element which appears to be more heterogeneous in sequence, the −10 element plays an essential role in promoter binding by stabilizing the initial interactions between the RNAP holoenzyme and the DNA promoter sequence, and consequently facilitating the subsequent isomerization of the promoter to an open form, exposing the DNA template strand [38].

Thus, the associated helicase stimulates dNTP binding by stabilizing the post-translocated state of T7 DNAP, and the outcome is decrease in dNTPs Km.

Substituting a S in G107-bearing TRBV, which we hypothesize acts by stabilizing the CDR3β rather than through altered binding to MHC, may potentially boost overall sensitivity without substantially altering specificity.

Whereas in conventional allosteric ribozymes, effector-binding modulates the chemical step of catalysis, here, effectors exercise their effect upon the substrate-binding step, by stabilizing the enzyme substrate complex.