Sentence examples for by specifically blocking the from inspiring English sources
However, a new class of drugs, AT1-receptor blockers, now offers a number of benefits by specifically blocking the effects of AII at its physiologically relevant receptor.
Another unique property of TIMP-3 is its ability to inhibit angiogenesis by specifically blocking the binding of VEGF-A to its receptor VEGF-R2.
TSA was further shown to interfere with cell cycle progression by specifically blocking the G1/S transition.
These findings suggest that overexpression of DKK-3, DKK-4, or sclerostin inhibit TNF-α expression by specifically blocking the Wnt channel.
In addition, the protection offered by specifically blocking the expression of profilin-1 against AGE-induced endothelial alterations has not yet been reported.
Accordingly, the antitumour actions expected to result from pharmacological blockade of HER2/HER3 dimer can be entirely mimicked by specifically blocking the autocrine expression of heregulin.
This original hypothesis is, however, modified [ 5, 9] based on the observation that SKCa-dependent hyperpolarization can be blocked not only by apamin, a SKCa channel inhibitor, but also by Ba2+ in concentrations specifically blocking the inward-rectifying K+ channels (Kir) [ 10].
The streptococcal protein CNE effectively inhibits αVβ3-directed PDGF-BB-stimulated collagen gel contraction by C2C12 cells through specifically blocking the binding of cell-produced fibronectin to the Col I fibres [ 36].
Since CSP-3 inhibits apoptosis by specifically blocking autoactivation of the CED-3 zymogen, we examined whether CSP-2B has a similar activity using an in vitro CED-3 autoactivation assay described previously 13.
The former can slow progression by breaking the stabilizing bonds between GAG and SAA in the deposits, in a manner analogous to that of eprodisate; 56 the latter seem to exert their effect through inhibition of the isoprenoid pathway by specifically blocking farnesyltransferase.
The functional relevance of longer DC-T cell interactions, associated with antigen conjugated to 200 nm particles, was dissected by specifically blocking later interactions, resulting in reduced Tfh induction, while the overall magnitude of the T cell response was unaffected.
