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These data further imply that the core transcriptional machinery may be modified by specific signalling pathways in order to alter the transcriptional regulation of gene sub-sets.
In cells, the assembly and disassembly of actin filaments and their organisation into higher-order networks is regulated by actin-associated proteins which, in turn, are controlled by specific signalling pathways [ 1, 4].
Apoptosis, the programmed cell death phenomenon driven by specific signalling pathways (reviewed in [ 37]) in response to stress conditions, also contributes to NRTI toxicity.
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The protein phosphorylation of signalling pathways in the process of IL-17A-mediated DVSMC activation was investigated and validated by specific signalling pathway inhibitor.
Diverse sources of MSCs include embryonic and extraembryonic lineages and adult tissues, such as bone, fat, and cartilage, each intricately regulated by specific signaling pathways.
It demonstrates that rapid modifications of actin cytoskeleton dynamics regulated by specific signaling pathways play a functional role in cell volume regulation.
This is consistent with preliminary studies indicating that HAMLET internalization is influenced by specific signaling pathways and by the metabolic state of tumor cells (P. Storm et al manuscript in preparation).
Together, these findings revealed that muscle atrophy is an active process controlled by specific signaling pathways and transcriptional programs.
Assembly and disassembly of actin filaments is controlled by a group of actin-binding proteins, whose activities in turn are regulated by specific signaling pathways.
We found that MT-II-induced LD formation is regulated by specific signaling pathways and that PKC, PI3 K, ERK1/2, but not p38MAPK are involved in the formation of LD induced by this PLA2 homologue.
These changes, including both reversible and irreversible ones, are not an all-or-none phenomenon, but are finely graded in a context-dependent manner regulated by specific signaling pathways [ 87].
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