Powerful techniques have been developed to process the sequencing data and to isolate the binding sites from the background noise generated by non-specific sequences, such as statistical tests, use of controls, techniques for signal de-convolution or lag-analysis among others [ 23].
Rather the nuclear uptake is likely to be mediated by specific sequences or domains within ARTD10 such as an NLS [ 16].
Although the H3 nucleosome is mainly distributed by the bending property of DNA sequences (Segal et al., 2006; Vafabakhsh and Ha, 2012), the H3K4me3 nucleosome is regulated by protein factors recognizing specific sequence compositions, such as non-methylated CG-rich sequence signatures.
Targeting of proteins for degradation is often achieved by specific protein sequences or posttranslational modifications such as ubiquitination.
Nevertheless, the DRB1 locus can be analysed successfully by deactivation of such sequence reads identified by DRB3/4/5 specific sequence motifs.
Such as, in communication channels, discrete signals generated by a specific sequence from a source could be corrupted by Gaussian noise in the transmission process; so, the received signals could deviate from the signal sequence [10].
Such controls include specific sequences for the hybridisation of detection primers and probe, but also an exogenic "Not I" sequence (detectable by a specific probe or cleavable by the Not I restriction enzyme).
Differences in expression of specific sequences are often validated by another method of analysis such as RT-PCR, Northern analysis or nuclease protection assays.
We suggest that thyroid and prostate-specific long non-coding RNAs are regulated by transcription factors that bind GC-rich sequences, such as EGR1, SP1 and E2F3.
The CRISPR-Cas9 endonuclease can be directed by guide RNAs to cleave specific sequences of DNA targets14,15,16,17.
