Sentence examples for by specific phosphorylation of from inspiring English sources

The latter two functions are regulated by specific phosphorylation of residues within the carboxy terminal domain (CTD) of the largest subunit of RNA polymerase II (RNAPII).

The AMPK/Snf1 signaling controls energy metabolism by specific phosphorylation of many metabolic enzymes and transcription factors, enhancing or suppressing their functions.

However, in our study, we show that, in vivo, MPTP treatment induces a progressive loss of TH-positive neurons concomitant with an increase of phospho-Tyr216 GSK-3β in remaining dopaminergic neurons, indicating that the activation of GSK-3β by specific phosphorylation of Tyr216 may be involved in the MPP+-dependent neuronal cell death process.

The tNTS contains two NLS regions (a.a. 82 88; 111–121) [ 14, 18, 19], as well as an exportin-1 (CRM-1) recognised nuclear export sequence (NES a.a. 97 105) which is inhibited by specific phosphorylation of threonine 108 in cancer cells [ 15, 16, 18, 20].

This action is mediated by the specific phosphorylation of p53 in Thr18 by VRK1 [19], [44], [45], [45].

It is known that the Myc-α-tubulin interaction is disrupted during mitosis by a specific phosphorylation of Myc at Thr-58, suggesting that the loss of such interaction at mitosis may be a physiological requirement for cell division [52].

Furthermore, MUC4 plays an important role in cell proliferation and differentiation of epithelial cells by inducing specific phosphorylation of ErbB2 and enhancing the expression of p27 (Jepson et al, 2002), a cyclin-dependent kinase inhibitor that regulates the G1 and S phases of the cell cycle (Polyak et al, 1994).

The critical regulation of PHF8 activity by specific phosphorylation has provided an alternative pharmacological approach for overcoming ATRA resistance in APL cells.

We next investigated the two major signaling cascades triggered by NGF in PC12 cells, the ERK and the PI3K cascades, analyzed by measuring the specific phosphorylation of the ERK 1/2 and Akt kinase, respectively (Fig. 2).

Virus infection is often connected with stress-related cellular processes, including induction of PKR- specific phosphorylation of eIF2α by double stranded viral RNAs [44], [48].

Tethering the PKA regulatory subunit(R) to specific subcellular sites by binding AKAPs helps to assure specific phosphorylation of specific targets and thus prevents uncontrolled phosphorylation.