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The activation of Squid and gurken anchoring could thus be brought about by specific modification of Squid in the oocyte nucleus by K10.
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QMC employs the monomolecular tetrahelical architecture of DNA and has two key components: (i) shape complementarity between QMC partners, which is introduced by specific modifications of the quadruplexes, and (ii) Mg2+ ions.
It is known that tumor cells acquire some of the required properties for growth and invasion by the specific modification of the tumor microenvironment.
The biological significance of the specific modification of Arg111 by dicarbonyl compounds and the role of Arg111 as a target for engineering xenobiotic substrate specificity were discussed.
Thus, IFNγ stimulation leads to a specific modification of C. trachomatis inclusions by recruiting four different IRGs.
However, in this work we show that Mg2+ ions are able to restore the tetrahelical structure of (G3T 2 disrupted by specific modifications (i.e., insertion or deletion of nucleotides) (Fig. S1).
The PFLPS system was developed by making specific modifications of the Tet-off regulation system (originally developed by Dr. Hermann Bujard [ 6]) to include the prostate-specific ARR2PB promoter (originally developed by Dr. Robert J. Matusik [ 7]).
Based on previously reported SAR information on LXY1 [16, 22, 23] and the aforementioned results from screening of focused OBOC libraries, we designed and synthesized 28 new peptide analogs of LXY1 by site-specific modification of individual amino acids (Table 2).
Regulation of GLI3 by the MID1-α4-PP2A complex could be mediated either by modifying phosphorylation of GLI3 in its PP2A-dependent regulation domain or by the phospho-specific modification of a GLI3 cofactor binding to that region.
Peptides were analysed for modification by BAY 11-7082 by the addition of a cysteine-specific modification of +C 3) H(1) N(1) (+51.011 Da) to Mascot.
The biological results were eventually linked to an enzyme-specific modification of DNA by type I R/M enzymes.
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