Sentence examples for by specific marks such from inspiring English sources
Transcriptionally active regions can be identified by specific marks, such as CpG islands, histone methylation (H3K4me3) peaks or DNAseI sensitivity hotspots.
Initially, the approach was validated by screening known interactors of specific Kme3 marks such as HP1 for binding H3K9me3 or the PRC2 subunit Suz12 for (indirectly) engaging H3K27me3.
Recent work has shown that active enhancers directly involved in transcriptional activation via chromatin looping are marked by specific chromatin modifications such as acetylation of lysine 27 of histone H3 (H3K27ac) [ 7, 8].
Taken together, these data indicate that hair cell lineage-specific genes in the mammalian supporting cells are tightly regulated by less dynamic epigenetics marks such as histone methylation and DNA methylation.
Enhancers can be identified by specific chemical marks associated with their DNA, but little is known about the enzymes that leave these marks in mammals.
We therefore analyzed whether interactions between domains defined by specific histone marks change in senescence.
Muscle-bone attachments leave characteristic marks, such as rugose surfaces bounded by raised ridges.
Look for specific marks and grooves.
The HSM determines which natural places are highly attractive by having people mark such places on a map.
However, in the first case, resolution was not sufficient to address important questions such as whether CO or GC events occur more frequently than expected in intergenic regions, or in regions marked by specific sequence elements or motifs.
