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Protein-based particles are highly biocompatible and biodegradable structures that can impart bioadhesive properties or mediate particle uptake by specific interactions with the target cells.

In vivo and in vitro studies of the contacts with cells have shown that the main interaction of liposomes with cells is either simple adsorption (by specific interactions with cell-surface components, electrostatic forces, or by non-specific weak hydrophobic) or following endocytosis (by phagocytic cells of the reticuloendothelial system, for example macrophages and neutrophils).

Natural hyaluronic acid is organized within the extracellular matrix by specific interactions with other matrix macromolecules.

Solvated Mg2+ ions bind to RNA by diffuse, nonspecific interactions with the backbone or by specific interactions with the RNA.

The catalytic conformation of the release factor, as shown in Figure 1B, is stabilized by specific interactions with the ribosomal decoding center.

Plant NBS-LRR and RLK proteins mainly function in host resistance by specific interactions with pathogen effectors, which trigger plant defense responses that inhibit pathogen growth and spread inside infected tissues [ 42].

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Our concept is to attain sequential targeting of tumor cells as shown in Fig. 7, i.e., nanoparticles are accumulated in the tumor tissue by the EPR effect and then they target tumor cells by specific interaction with the CD44 receptor on the tumor cell membrane followed by receptor-mediated endocytosis of them.

In the initiatory translocation step, SecB targets the preprotein to the translocase by specific interaction with its receptor SecA.

PC-SA liposomes kill Leishmania by specific interaction with surface phosphatidylserine (PS) of promastigotes and amastigotes [30].

Our data support the growing consensus that the nucleolar accumulation of ribosomal proteins may not be mediated by a defined localization signal, but rather by specific interaction with established nucleolar components such as rRNA.

This is achieved by specific interaction with the inverted complementary repeat sequence, ICRIII, carried by the plasmid that encodes RepD.

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