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Repair of damaged tissue and of supraspinal connectivity/circuitry following spinal cord injury in rat can be achieved by specific cell elimination with radiation therapy of the lesion site delivered within a critical time window, 2-3 weeks postinjury.
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The pathologic outcome of spinal cord transection and contusion injury can be manipulated and intrinsic wound repair obtained by specific elimination of some cells generated at the lesion site [3], [19] [20].
Using this system we have conducted unbiased functional screens to identify factors that confer resistance to cancer cell elimination by antigen-specific cytotoxic T cells.
We recently designed and constructed chimeric proteins for the elimination of specific cell populations.
Blocking the PD-1/PD-L1 pathway can revert this condition, promoting cancer cell elimination by activated T-cells.
Thus, how JNK executed cell elimination remained elusive.
FR806, therefore, constitutes a specific cell-surface marker for the elimination of transduced T cells.
Viruses favor specific cells.
However, differences in the cytokine elimination by specific membranes during CHF have not yet been fully investigated.
Blocking IL-16 by specific Abs led to T. whipplei elimination within phagolysosomes.
These examples clearly illustrate the effective and specific elimination of cells in different species by the use of barnase gene expression; however, little work has been focused on the effects of exogenous addition of barnase on malignant and normal mammalian cells.
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