Sentence examples for by somatic activation of from inspiring English sources
Thus, isolated congenital macrodactyly is caused by somatic activation of the PI3K/AKT cell-signaling pathway and is genetically and biochemically related to other overgrowth syndromes.
In addition, aberrant somatic activation of SRC is frequent in human cancers including thyroid cancers.
Somatic activation of telomerase helps to confer these features in many tumour types.
First, somatic activation of AKT, a downstream target of PI3K, was recently described in patients with Proteus syndrome (13).
Improvement in sleep was accompanied by improvement in mood, in daytime drowsiness, in insomnia indices such as the insomnia severity index, in dysfunctional beliefs and attitudes about sleep and in the state of cognitive and somatic activation prior to going to bed.
In the majority of pallidal neurons, HFS gave rise to somatic activation.
Similarly, the Ink4/Arf locus which encodes three transcripts of p16Ink4a, p19Arf, and p15Ink4b tumor suppressors acts as a main barrier of pluripotent reprogramming in both human and mouse somatic cells by activation of the p53-p21 pathway.
Aberrant activation of Janus kinase 2 (JAK2) caused by somatic mutation of JAK2 (JAK2V617F) or the thrombopoietin receptor (MPLW515L) plays an essential role in the pathogenesis of myeloproliferative neoplasms (MPNs), suggesting that inhibition of aberrant JAK2 activation would have a therapeutic benefit.
Low efficiency of somatic cell reprogramming can be partially explained by the activation of TP53 pathway and INK4/ARF locus by reprogramming factors.
Further, patients with NP rate their level of pain relief to be significantly lower than those with nociceptive pain (defined as pain caused by activation of primary afferents in somatic or visceral tissues) in response to a single dose of an opioid [ 8, 9].
