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The peptide was produced by solid phase methods [39] in an ABI 433A synthesizer (Applied Biosystems, Foster City, CA), using Fmoc (9-fluorenylmethoxy carbonyl) chemistry and 0.1-mmol-scale FastMoc protocols.
Foldamers 5– 8 were synthesized by solid phase methods as described in the Supporting Information.
Oligodeoxynucleotides were synthesized by solid phase methods using an ABI 394 DNA synthesizer (Life Technologies, Carlsbad, CA).
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Tripeptide as an activator of SIRT1 were screened on the basis of structural information by molecular docking and synthesized by solid phase method.
A total of twenty four binuclear metal azaphthalocyanine compounds in four series of M2 azaPc 2Me, M2 azaPc 2SO2, M2 azaPc 2, M2 azaPc 2CO (M = Mn2+, Fe2+, Co2+, Ni2+, Cu2+, Zn2+) were synthesized by solid phase method, which were applied for Li/SOCl2 battery as electrocatalysts to enhance its capacity and discharge voltage.
VP1211 225 (peptide sequences: FGEHKQEKDLEYGAC) and VP2136 150 (peptide sequences: AGGTGTEDSHPPYKQ) were synthesized in-house by solid phase method using an automated multichannel parallel peptide synthesizer (model Prelude from Protein Technologies, Inc ., employing the fluorenylmethoxycarbonyl (Fmoc) group for α-amino group protection.
Several complex natural products have now been synthesised by solid-phase methods and have created the foundation for preparation of combinatorial libraries.
In contrast, the chemical synthesis of RNA by solid-phase methods offers advantages over biochemical approaches.
We have reported the synthesis of oligonucleotides containing the N-methyl-Fapy-dGuo lesion (MeFapy-dGuo) by solid-phase methods.
They were chemically synthesised by solid-phase methods, using Fmoc (9-fluorenylmethyloxycarbonyl) with a Pioneer™ Peptide Synthesis System (Applied Biosystems, CA, USA).
The peptides LTX-302, LTX-315 and LTX-318 were synthesized by solid-phase methods using standard Fmoc chemistry on a Pioneer Peptide synthesizer (Applied Biosystems, Foster City, CA).
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