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Tripeptide as an activator of SIRT1 were screened on the basis of structural information by molecular docking and synthesized by solid phase method.
A total of twenty four binuclear metal azaphthalocyanine compounds in four series of M2 azaPc 2Me, M2 azaPc 2SO2, M2 azaPc 2, M2 azaPc 2CO (M = Mn2+, Fe2+, Co2+, Ni2+, Cu2+, Zn2+) were synthesized by solid phase method, which were applied for Li/SOCl2 battery as electrocatalysts to enhance its capacity and discharge voltage.
VP1211 225 (peptide sequences: FGEHKQEKDLEYGAC) and VP2136 150 (peptide sequences: AGGTGTEDSHPPYKQ) were synthesized in-house by solid phase method using an automated multichannel parallel peptide synthesizer (model Prelude from Protein Technologies, Inc ., employing the fluorenylmethoxycarbonyl (Fmoc) group for α-amino group protection.
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The peptide was produced by solid phase methods [39] in an ABI 433A synthesizer (Applied Biosystems, Foster City, CA), using Fmoc (9-fluorenylmethoxy carbonyl) chemistry and 0.1-mmol-scale FastMoc protocols.
Oligodeoxynucleotides were synthesized by solid phase methods using an ABI 394 DNA synthesizer (Life Technologies, Carlsbad, CA).
Foldamers 5– 8 were synthesized by solid phase methods as described in the Supporting Information.
To date, the researchers' efforts have mainly been directed towards the studies of manganites synthesized by solid-phase method.
Peptides structurally related to the BbKI (RPGLPVRFESPLRINIIKE-NH2) reactive site were synthesized by solid-phase method and assayed for serine proteinase activity.
A tetrapeptide combinatorial library, considered as chromogenic substrates of bovine β-trypsin, was synthesized by the solid phase method.
Peptides MIASHLLAYFFTELNβA-GYGRKKRRQRRRG (TAT-HK) and GYGRKKRRQRRRG-βA-EEEAKNAAAKLAVEILNKEKK (TAT-Ctr) were synthesized by a solid phase method using an automatized peptide synthesizer (model 431-A, Applied Biosystems, Foster City, CA).
All peptides were synthesized by the solid phase method using a CEM Liberty automatic microwave peptide synthesizer (CEM Corporation, Matthews, NC), applying 9-fluorenylmethyloxycarbonyl (Fmoc) chemistry [35].
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