Furthermore, MSC differentiation patterns indicated that specific combinations of scaffold strains and inlet fluid flows cause phenotype assemblies dominated by single cell types.
Cartilage is made and maintained by a single cell type, the chondrocyte.
The cartilage remodelling process is conducted entirely by a single cell type, namely the chondrocyte.
These metabolic features of proline and collagen metabolism may not be provided by a single cell type.
The luminal ER+ population is also unlikely to represent a completely uniform cell population but as the majority of the cells are strongly keratin 18 positive and express the estrogen receptor [ 5], the gene expression profile of this population will be dominated by this single cell type.
Furthermore, while other studies had observed exon marking across expressed genes by analyzing a single cell type, our data points to aspects of this marking as being cell-type specific, combinatorial, and related to levels of transcription – with even untranscribed genes having exon-intron marking biases.
Furthermore, it can be used to understand not only how disease states can arise by defects in a single cell type but also how it can arise as a result of the breakdown in cooperation between different cell types.
Previous studies have mapped the binding patterns of TFs between species, including mouse and human, by focusing on a single cell type and a few TFs (e.g., [ 32]).
This study provides a proof-of-concept method for construction of AIM panels by integrating SNP and GE markers but the current results are still limited by the use of single cell type (lymphoblastoid cell lines), fixed time/circumstances of taking the biological samples, and single microarray platform (Illumina's Sentrix Human-6 Expression BeadChip).
The current results are still limited by the use of a single cell type, lymphoblastoid cell lines (LCL).
