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Such a neuron would be activated by simultaneous activation of the two vertical or the two horizontal layers.
It seems likely that the enhancement of bone formation by OCP is accompanied by simultaneous activation of osteoclastic resorption of OCP.
The protective effect was further enhanced by simultaneous activation of several prosurvival kinases [ 20].
It is unlikely to be driven by simultaneous activation of JNK upon polarity loss, since co-activation of Yki and JNK does not recapitulate neoplastic growth phenotypes.
Plants accumulate proline in response to freezing-induced osmotic stress by simultaneous activation of proline biosynthesis (via the P5CS1 pathway) and/or down regulation of proline degradation (via the ProDH pathway) [ 35].
In summary, modulation of PKC by simultaneous activation of PKC δ and inhibition of PKC α using PEP005, displayed antiproliferative effects due to late G1 cell cycle arrest and/or apoptosis induction at concentrations that may be reached in clinical trials.
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Thus, we can envision a scenario characterized by the simultaneous activation of apoptotic and anti-apoptotic pathways, whose balance is finely modulated during infection with Shigella toward the eventual commitment to death of the infected cell.
Based on pharmacological intervention and mutagenesis data, we propose a coincidence detection model in which the conditions for NCKX4 stimulation can only be fulfilled by the simultaneous activation of PKC and CaMKII.
In particular, the critical observation that FcεR activation of mast cells can be downregulated by the simultaneous activation of inhibitory FcγRIIB (Daeron et al, 1995), has stimulated the development of a number of Fc-fusion proteins that inhibit inflammation, and which may have particular application in treating allergic asthma (Supporting Information Table S1).
14– 16 In addition to the tried and tested local application of electromyostimulation with its directly stimulating effect on the rate of skeletal muscle protein synthesis, 16 WB-EMS enlarges this effect by its simultaneous activation of a total area of 2.800 cm (16 regions, Figure 2) with different dedicated intensities/regions, and thus extends the potential of electromyostimulation.
Nitrogen- and oxygen-containing hierarchical porous carbon frameworks have been successfully synthesized by carbonization and simultaneous activation of polyaniline with KOH as activating agent.
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