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However, by simulating from the posterior distributions of all parameters it is possible to provide estimates of directly interpretables1 quantities such as the probability that a rater will agree with the modal class.
This large study in 102 neonates and infants developed dosing guidelines based on achieving time greater than in vitro IC50 values by simulating from the PK model.
At its core, this method involves a single proposal function, which updates the structured tree by 'dissolving' a randomly selected edge and drawing a new edge by simulating from the structured coalescent conditional on the remaining edges.
For plots produced by the plot.gam function of the mgcv package, Bayesian confidence intervals are used for plotting of the smooth terms, which can be obtained by simulating from the posterior distribution of the functional coefficients (or varying coefficients) [ 39] For model selection, esting between nested models was performed using anova(model 1,model 2, test="Chisq") [ 39].
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As described in the methods, due to the small sample size and number of FOVs, the biomarkers besides MAP-Tau were imputed by simulating from a normal distribution based on the observed mean and standard deviation of the each individual biomarkers.
The data were generated by simulating from a thermodynamic model for gene expression to which Gaussian noise was added.
This is done by generating new data by sampling and simulating from the posterior distribution, and then comparing the resulting distribution of goodness-of-fit (GOF) with the GOF from the experimental data [ 11, 50, 61].
D. Cox non-nested test with a parametric bootstrap Cox non-nested test with a parametric bootstrap Under a given null model (e.g. either FE or DB), each bootstrapped sample of the data (new infections) was generated by simulating draws from the Poisson process governing arrivals of new infections based on the fitted estimates of the mean arrival rate for new infections, λ t ∀ t = 1, …, 50.
We also tested the robustness of our algorithm to less ideal sequencing conditions by simulating reads from the whole human genome with clones with triple the standard deviation in clone size (30 Kb) as well as a standard deviation of 20% in the number of reads obtained from each clone.
The VPCs were obtained by simulating predictions from the model based on 12-week data for each arm, 500 times.
The reconstruction process is performed by simulating the diffraction from the digital hologram when illuminated by the reference wave.
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