Sentence examples for by silencing the expression from inspiring English sources

Ischemia-induced EndoG translocation and DNA degradation are prevented by silencing the expression of Bnip3, but not Nix, or by overexpressing Bcl-xL.

However, the constitutive promoter-driven expression of an RNAi/antisense-transgene could cause pleiotropic phenotypes or embryo lethality by silencing the expression of the target gene and its homologs, thus making it extremely difficult to study the functions of the target gene or to define a causal relationship between a silenced gene and the observed phenotypic alterations.

It is currently believed that miRNAs elicit their effect by silencing the expression of target genes [ 34].

Subsequently, the oncogenic properties of the fusion protein were explored by silencing the expression using RNA interference in a cell line derived from one of the tumors.

These results demonstrated that targeting GSH production by silencing the expression of GCLc or GCLm is sufficient to induce a slowly progressive loss of nigral DA neurons, whereas targeting GSH recycling by silencing the expression of GSR is insufficient to induce such neuronal loss.

The inhibition of autophagy by silencing the expression of the proteins ATG7 or Beclin-1 prevents the increase of SA- β-Gal staining in response to imatinib plus Z-Vad.

In this study we demonstrated successful disruption of the first step of phytic acid biosynthetic pathway in transgenic rice plants, by silencing the gene expression of the enzyme myo-inositol-3-phosphate synthase.

One study showed that in gemcitabine resistant cell lines, sensitivity to this agent could be rescued by silencing the RRM1 expression (> 90%) with iRNA [ 10].

Similar results were observed by mean of silencing the expression of c-Jun with siRNA.

These genes become active whenever living system is challenged with some kind of physical or chemical insult or stress, in a bid to combat the stress-related damage, either by activating or silencing the expression of some other sets of genes.

Since we found in STK35L1-silenced cells an acceleration of the G1/S- phase transition, we expected that by STK35L1-silencing the expression of those genes might be altered, which function during G1/S phase transition.