Sentence examples for by significant side effects from inspiring English sources
Furthermore, these small to moderate short-term improvements in sleep are often outweighed by significant side effects and risks, particularly in older adults.
These therapeutic interventions are still limited by significant side effects.
Unfortunately, the topical treatments for OH are often accompanied by significant side effects [ 48, 49].
18– 20 Although gentamicin treatment has produced promising results, its use can be accompanied by significant side effects that may limit long-term administration.
No single chemotherapeutic agent currently offers a response rate greater than 25%, and treatment is invariably accompanied by significant side effects, including myelosuppression, nausea and emesis [ 1, 2].
No single chemotherapeutic agent currently offers a response rate greater than 25%, and treatment is invariably accompanied by significant side effects, including myelosuppression, nausea and emesis [ 2- 4].
The use of cisplatin is frequently limited by various significant side effects such as bone marrow suppression, peripheral neuropathy, ototoxicity, anaphylaxis, and nephrotoxicity.
Given the heated debate regarding corticosteroids in septic shock and the role that etomidate may play in leading to adrenal insufficiency, enthusiasm for etomidate as an induction agent should be tempered by its possible, significant side effects in these critically ill patients.
Paclitaxel, an antimitotic agent derived from bark of Pacific Yew tree Taxus brevifolia (Schiff et al, 1979), proved to be active in relapsed and platinum-resistant ovarian cancer (McGuire et al, 1989; Einzig et al, 1992; Trimble et al, 1993; Kohn et al, 1994; Gore et al, 1995) and was well tolerated by most patients: significant side effects other than alopecia were uncommon (Seidman et al, 1996).
Since the goal of the stabilization phase is to consolidate stability of remission, adjustment of the doses of study medications is allowed, if necessitated by clinical worsening or significant side effects.
There was a consensus that the studies are of potentially high impact because they suggest a mechanism by which drugs with significant side effects, such as FK506, can be selectively delivered to target cells.
