Sentence examples for by signal transducer and from inspiring English sources
These immunosuppressive hypoxic effects were mediated by signal transducer and activator of transcription 3 (STand) and its transcriptionally regulated products such as hypoxia inducible factor (HIF -1α and vascular endotHIF -1αgrowth fandor (vascular
Bioinformatic analysis revealed that the miR-21 promoter can be targeted by signal transducer and activator of transcription 3 (STAT3).
It is well known, that IL-6 and IL-10 signalling is mainly supported by signal transducer and activator of transcription 3 (STAT3).
Several prior studies have found that receptors containing isoleucine at position 50, compared with receptors containing valine at the same position, support increased signaling as measured by signal transducer and transactivator 6 phosphorylation [ 21, 27- 29].
The latter hypothesis was considered to be a reasonable possibility since IL-6 signaling is known to activate proliferative and survival pathways in target cells, including those mediated by signal transducer and activator of transcription-3 (STAT3), extracellular signal-regulated kinase 1/2 (ERK1/2), and the bcl-2 family of apoptotic regulators [ 26- 28].
Cytokine signals are mediated by Signal Transducer and Activator of Transcription family of proteins, which together with T cell receptor signaling activate subset-characteristic transcription factors, most importantly T-bet, Gata3, RORc and Foxp3, promoting the development of Th1, Th2, Th17 and iTreg cells, respectively.
Aberrant growth stimulation by Signal Transducers and Activators of Transcription (STAT) is implicated in human carcinogenesis.
We found that JMJD2B suppression remarkably stimulated the DDR, and consequently induced tumour cell cycle arrest, apoptosis, and senescence, which is partially regulated by signal transducers and activators of transcription 3 (STAT3).
The promoter region glucocorticoid response elements, metal response elements, the antioxidant response elements, and the elements activated by signal transducers and activators of transcription are present in the upstream of the chromosome that codes for MT gene, and are known to be involved in the expression of MT induced by glucocorticoids, zinc, activated oxygen, and cytokines [ 39].
The resulting free radicals initiate the inflammatory process in the cochlea by activating signal transducer and activator of transcription-1 (STAT1), followed by activation of p53 and increase in inflammatory mediators like TNF-alpha and interleukin-1 β [ 23].
The tumor hypoxia induced immune suppression is modulated by the signal transducer and activator transcription 3 (STAT3) pathway and hypoxia inducible factor (HIF -1α, wHIF -1αn be reversed whichSTAT-3 and HIF-1α inhibitors and indicanes hypoxia-mediated immune suppression can be overeversedth inhibitors.
