Sentence examples for by side effects such from inspiring English sources

Clinical investigation of melatonin agonists has been hampered by side effects such as hypothermia, hypotension and bradycardia.

However, the tolerability of these orally administered drugs is limited by side effects such as gastro-intestinal symptoms [ 13– 15].

Optimal drug therapy may also be limited by side effects, such as hypoglycaemia, body weight gain and oedema.

These so-called "pan-HDAC inhibitors" lack specificity for individual HDAC enzymes and are consequently accompanied by side effects such as worsening of atherosclerosis and immunosuppression.

This association probably results from increased risk of falling caused by side effects such as sedation, impaired balance and reduced cognition [ 9, 14, 33].

COPD patients treated with the PDE4 inhibitor roflumilast show an improvement in lung function; however, the clinical efficacy of roflumilast is limited by side effects such as nausea, diarrhoea and headaches [ 121].

High-dose IL-2 regimens are limited by side-effects such as pulmonary oedema and a systemic vascular leak.

In addition, orlistat, the only pharmacological intervention currently approved in the United States for the treatment of obesity in children and adolescents [ 93], has been shown to be less cost-effective than several nonpharmacologic interventions, including exercise [ 87, 94], and has also been accompanied by side-effects such as gastrointestinal distress [ 95].

When comparing experimental threshold values for LIOB in water, numerous values for threshold pulse energy, radiant exposure, or irradiance are available which depend on parameters such as wavelength, pulse duration, and numerical aperture, and which are additionally influenced by side-effects such as self-focusing and aberrations.

However, in spite of therapeutic success in the treatment of several types of tumors, their effectiveness is severely hindered by adverse side effects such as nausea, ototoxicity, neurotoxicity, myelosuppression, and nephrotoxicity.

Opioid use for long-term pain management is limited by adverse side effects, such as hyperalgesia and negative affect.