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The efficacy of widely used cancer chemotherapeutics is frequently limited by side effects resulting from narrow therapeutic windows between a drug's beneficial anticancer activity and its general cytotoxicity.
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Although it is often possible to identify a single kinase that plays a pivotal role in a given disease, the development of drugs based upon protein kinase inhibition has been hampered by unacceptable side effects resulting from a lack of target selectivity.
Side effects resulting from the combination were mild and transient.
The side effects resulted in many of the housing problems we face today.
No obvious side effects resulted from this conduct.
The availability of this information is likely to translate directly into benefit to patients, by helping optimise dosage and preventing side-effects resulting from over-dosing or lack of effectiveness resulting from under-dosing.
However, methadone is limited by side effects influencing compliance, resulting in inadequate treatment retention 5, 6.
The inflammation is exacerbated by side effects of the medicines.
Current treatment of solid tumors is limited by side effects that result from the non-specific delivery of drugs to the tumor site.
Systemic application of IFN-alfa is limited by side effects.
Difficulties caused by side effects were broad.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com