The therapeutic efficacy of cytokines is often hampered by severe side effects due to their undesired binding to healthy cells.
However, the clinical uses of general proteasome inhibitors are often limited by their side effects due to their non-selective inhibition of protein degradation.
The significant treatment effect favoring IFN seen in E1684 with respect to both relapse- free survival (RFS) and overall survival (OS) was expected and was accompanied by substantial side effects due to the high-dose regimen.
The reduced activity could be explained in part by the side effects due to a nonselective HDAC inhibition that is responsible for hyperacetylation of numerous protein networks in cells.
The administration of GCs may be accompanied by mostly unwanted side effects due to their influencing the physiological processes in the body.
The use of molecular cancer therapeutics is often limited by life-threatening systemic side effects due to high drug dosage and non-site-specific targeting [32].
This percentage of ETR observed in our study has been reduced by the high incidence of side effects due to the overlapping toxicity of both antiretroviral and interferon therapy.
However, the aforementioned approaches may be accompanied by a number of severe side effects due to the disruption of proper vessel function in various organs (Eremina et al, 2003, 2006; Kamba et al, 2006; Verheul & Pinedo, 2007; Chen & Cleck, 2009; Boehm et al, 2010).
It included sociodemographic questions about the child and its parents (but not the parents' age), questions about the vital status of the parents (if available), access to care, compliance with ART by the child, difficulties and any side effects due the medication, problems related to treatment, and attendance at school.
Related to adverse side effects due to reirradiation by SRS, early toxicity as headache, nausea, vomiting, and so forth is medically managed, while late complication involves radiation necrosis that typically develops one to three years after radiation.
