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In this context, their accuracy and precision has been questioned by several studies using thermodilution or echocardiography as reference methods [25, 26].
The natural N- and C-termini, i.e., the given order of secondary structure segments, are critical for protein folding and stability, as shown by several studies using circularly permuted proteins, mutants that have their N- and C-termini linked and are then digested at another site to create new termini.
The ability of DCs to prime HIV-specific responses in vitro has previously been established by several studies using various antigen preparations, e.g. peptides, proteins, liposome complexed proteins and cDNA[11], [12], [13], [14] but not whole virions, the most physiologically relevant source of HIV-antigens.
These findings have since been confirmed by several studies using conventional MRI [ 38, 46, 48].
Sleep disruption is common in ICU patients and has been characterized by several studies using polysomnography (PSG) [ 1- 3].
It was expected that the highest gene expression to be detected would be at day 2 after instillation, as has been noted by several studies using GL67 as the gene carrier [ 31].
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By contrast, several studies using less sensitive in situ hybridization methods for the detection of viral plus- and minus-strand RNA nonetheless provided evidence for much more robust HCV RNA replication levels [17], [18].
By now several studies using this protocol, but without the addition of TBI to the non-myeloablative chemotherapy regimen, have shown a highly consistent objective response rate of 40 50% of treated patients.
Longnecker et al. (2003) addressed this by comparing PCB exposure across several studies using median concentrations of the most prevalent PCB congener (PCB-153).
The activation of γδ T cells by bacterial metabolites has been demonstrated in several studies using bacterial extract and supernatants containing purified antigens [20], [22].
Along with one study that identified type of diabetes by national registry (5), several studies used the age of onset of diabetes (18– 24, 29, 29) as a proxy for a presumptive diagnosis of type 1 or type 2 diabetes (Tables 1 and 2).
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