Radiation therapy (RT) of the head and neck region is often accompanied by serious side effects.
Conventional pharmacotherapy with non-steroidal anti-inflammatory drugs or opiates is often accompanied by serious side effects.
However, these methods may be limited by serious side effects, such as the spreading of cancer cells after incomplete excision, serious toxicity to normal cells during radiotherapy, and poor survival rates [4].
In addition, such drugs may be accompanied by serious side effects [ 11, 12].
In summary, there is evidence that the achievement of glycemic goals is difficult and accompanied by serious side effects that partly mask the benefits.
Extended field radiation may be useful in patients with diffuse metastases, but is often accompanied by serious side effects (Lewington, 1993).
Whereas evident antitumor properties has been addressed to date in a plethora of carcinoma cell lines, the present clinical application of GA is plagued by its serious side effects, such as phlebophlogosis, myelosuppression, and oral ulcers [7].
Glucocorticoids are an essential tool in combating inflammatory disorders, however their use is limited by multiple serious side effects.
Positive results would encourage a new approach in managing UC patients to avoid or delay step-up therapies with drugs burdened by potentially serious side effects.
However, it's clinical use is limited by its serious side effects including bone marrow depression [ 7], liver and kidney injury [ 8, 9], and cardiac toxicity [ 10].
For instance, corticosteroid therapy is associated with diabetes, hypertension, infection, and osteoporosis (6), and treatment with immunomodulators may be complicated by rare but serious side effects that can include bone marrow suppression, hepatotoxicity, opportunistic infection, an increased risk of lymphoma, and pancreatitis (6, 7, 8).
