Sentence examples for by sequestering the active from inspiring English sources

The antibiotic streptolydigin inhibits RNA polymerase by sequestering the active center in a catalytically inactive conformation.

I-Smad mediates a negative feedback by sequestering the active receptor (5 and 6) and can be degraded (19).

PAK has also been shown to play a non-catalytic role in driving actin depolymerization by locally sequestering the active (GTP-bound) GTPases Cdc42 and Rac (Bisson et al., 2007).

Wild-type SQSTM1 exists in equilibrium where the stability of the UBA dimer regulates ubiquitin-binding by sequestering the biologically active monomeric UBA [27].

This review focuses on the formulations sequestering the active drug in a vehicle with the aim of modifying its distribution and elimination and finally its duration of action.

Given the general sequence homology between these exotoxins and ADP-ribosylating toxins of known structure, we initially expected that 14-3-3 14-3-3 14-3-3 unlock an active exotoxin conformation bindingestering the LDLA-box containing C-termight.

Cellulase adsorption to lignin reduces cellulase activity by sequestering the enzyme away from its substrate.

This subsequently activates downstream caspases and by sequestering the antiapoptotic protein Bcl-2.

Our data are consistent with IMP-L2 regulating IIS by sequestering the DILP ligands.

These proteins promote cell survival by sequestering the proapoptotic proteins Bax and Bak [ 67, 68].

In this way, trigger loop closing helps to frame and sequester the active site.