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Hepatic P-gp and MRP1,2 could therefore be assessed by sequential use of both MIBI and HIDA.
Enzymatic products were then separated by two-dimensional TLC (2D-TLC) by sequential use of two customized mobile phases in order to discriminate molecular compounds that may differ for a single atom of hydrogen.
In an outbreak investigated by Bidet et al., the cause of the skeletal infections was determined by sequential use of real-time PCR targeting the K. kingae specific toxin rtxA and the cpn60 genes (35 ).
At the same time, a reliable purification method for plasma AGP by sequential use of ion-exchange cartridges was developed and followed by specifically labeling cleaved N-glycans from purified AGP.
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This is in contrast to whole exome sequencing (WES) and whole genome sequencing (WGS) where one tries to identify the disease-causing mutation directly, often by the sequential use of a set of heuristic filters4.
Theoretical modelling of Norton Simon (1986) clearly indicates that cell kill can be substantially increased by the sequential use of cytotoxic regimens.
Recently, the median survival could be improved by the sequential use of neo-adjuvant chemotherapy, extensive thoracic surgery including pleuro-pneumectomie and adjuvant radiation therapy [ 4- 6].
Of note, IL-12p70 release was almost completely abolished by the combined sequential use of R848 and CC [mean relative decrease 0.97 (±0.06)].
By means of the sequential use of these tools it is possible to create analysis pipelines, which in some cases can lead to new predictions.
However, sequential use of PTH followed by alendronate is highly effective at increasing BMD (Black et al 2005).
High antenatal care use vis a vis low skilled attendant at delivery could partially be explained by observed patterns in the concurrent and sequential use of multiple sources of care.
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