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The aim of this study was to examine the efficacy of SAAD by sequential monitoring of physiological and serological parameters.
To avoid life-threatening events such as diabetic ketoacidosis, early detection of the development of type 1 diabetes by sequential monitoring of anti-islet autoantibodies and blood glucose before and during interferon therapy is important.
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The CUSUM chart method, first described by Page in 1954[ 3], is based on sequential monitoring of a cumulative performance measure over time.
Thus, sequential monitoring of LS in compensated cirrhotic patients is desirable in order to properly assess the prognosis.
Similarly, von Bubnoff et al (2002) noted an increase in the proportion of mutant mRNA with sequential monitoring of relapsing patients.
Fluorescent measurements were obtained once in each cycle by sequential fluorescence monitoring of each sample tube at the end of extension.
To integrate multistage testing into the targeted designs enhances flexibility of targeted trials by enabling sequential monitoring and stochastic curtailment.
For the application of trial sequential analysis to severe hypoglycaemia, the protocol assumed an increase in relative risk of 30%, equivalent to a number needed to harm of 50, to construct the trial sequential monitoring boundaries.
The cumulative z curve touched the conventional boundary for harm but did not cross the trial sequential monitoring boundary for harm (trial sequential analysis adjusted 95% confidence interval of trials with low risk of bias 0.95 to 1.29) (fig 3).
Trial sequential analysis uses the Lan-DeMets trial sequential monitoring boundaries based on a O'Brien-Fleming alfa-spending function because the sample sizes of the included trials vary.
Trial sequential analysis showed that only 3.84% of the required information size to detect or reject a 10% relative risk reduction was accrued so far, and the trial sequential monitoring boundaries were not crossed (figure 4B).
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