Sentence examples for by sequential induction of from inspiring English sources

Using insights from mammalian liver development, we developed a differentiation protocol to generate hepatocyte-like cells from hESC by sequential induction of primitive streak/mesendoderm/definitive endoderm, followed by gradual hepatic maturation.

Adipocyte differentiation is characterized by marked changes in the pattern of gene expression that are achieved by sequential induction of various transcription factors [ 4].

Thus, TNF-induced gene expression could be sustained and amplified by the sequential induction of IRF1, IFN-β and STAT1.

Consistent with the bHLH gene being a target for regulation by ARF19, we observed the sequential induction of ARF19 and then RSL4 mRNAs in our transcriptomic time course dataset (Fig. 4d and Supplementary Fig. 5b).

We tested this possibility by examining the patterns of sequential induction of ROS-bZIP1 and representative subset of as1/ocs-like element-containing Group-II genes by integrating the qPCR expression profiles shown in Figures.

During carcinogenesis, multiple rounds of sequential induction of fragile sites by replication stress and carcinogen action could result in global hypomethylation.

Overall, the changes induced by PICP in tumors are consistent with the sequential induction of gene expression reported in vitro.

Although the authors did not find direct evidence so far for malignant conversion of KAs into SCCs, the sequential induction of both tumour types by the same oncogene suggested common transformation mechanisms.

We suggest the sequential induction of Foxp3 and miR-155 by H. pylori keeps the cAMP pathway functional in order to achieve a long-lasting modulation of the immune system [45].

One is sequential induction of successive cell layers from surrounding mesenchyme.

RA therefore mediates sequential induction of the Bhlh transcription factors Ngn3, Bhlhb2, and NeuroD that promote the generation of endocrine cells, followed by induction of the homeobox gene, Pax4, that determines β-cell identity, and finally the generation of insulin producing β-cells that express the homeodomain proteins Ipf1/Pdx1, Nkx6.1 and Hb9 (Fig. 4c).