Sentence examples for by sequential immunizations with from inspiring English sources
Here we propose a strategy of inducing broadly-reactive anti-stalk antibody by sequential immunizations with live attenuated influenza vaccines (LAIVs) expressing chimeric HAs (cHAs).
This study aimed to compare the immunological efficacy and safety of pneumococcal vaccination with the 23-valent polysaccharide (PPS) vaccine alone to a sequential immunization with the 7-valent pneumococcal conjugate (PnCj) vaccine followed by PPS in patients with SLE and stable diseaase.
The strategy utilizes sequential immunization with chimeric hemagglutinin-based vaccines expressing exotic head domains, and a conserved hemagglutinin stalk.
Our data establish that sequential immunization with specifically designed immunogens can induce high levels of somatic mutation and shepherd antibody maturation to produce bNAbs from their inferred germline precursors.
A major focus was to evaluate the effect of simultaneous and sequential immunization with vaccines representing different strains of HIV-1 on the ability to broaden cross-reactivity of antibodies against these and other HIV-1 strains.
The objective of this study was the preclinical evaluation of a sequential immunization strategy with cHAs to induce HA stalk-specific immune responses that confer protection against influenza virus infection.
Thus, the number of potential epitope containing library peptides could be minimized from initially 64 to 4 by two sequential immunization steps.
Sequential immunizations had less effect on the number or specificity of the cytokine-producing cells.
Furthermore, antibody titers of pr4 increased progressively with each sequential immunization.
An immunization scheme was designed for the sequential immunization of animals by direct vector injection followed by protein booster immunization using influenza HA produced in vitro from MVA vector infection of cells in culture.
Somewhat greater support for pursuing antigens presenting oligomannose-type glycans only has come from another study44 showing the elicitation of PGT121-like nAbs after sequential immunization of PGT121gl precursor-transgenic mice with a series of engineered native-like recombinant HIV trimers.
