Sentence examples for by sequence context and from inspiring English sources

The findings here suggest that Ape1 ssAP and dsAP endonuclease activities are regulated by sequence context and the relative concentrations of certain chemical elements in vivo, and that Ape1 incision activity occurs on complex replication, recombination, and/or transcription DNA intermediates.

The rate of cleavage can be influenced by sequence context and fold of the protein.

The mutability of individual CpGs can be determined by accounting for the influence of surrounding CpG density, as well as by sequence context and nucleosome position., Regions of CpGs that remain hyperconserved have been found to co-locate with polycomb repressive complex 2 binding domains and developmental genes.

The detection sensitivity of the HRM screening method was influenced by both sequence context and specific nucleotide change and varied from 1: 4 to 1 1000 (variant to wild-type DNA).

The chemical mechanism of MMC has been well documented in vitro: MMC preferentially interacts with guanines, the reactivity of which is affected by the sequence context, and additional studies have implicated specificity of interstrand crosslink formation at 5′-CpG-3′ sequences (Gargiulo et al. 1995; Kumar et al. 1992; Borowy-Borowski et al. 1990).

Although average error rates are constantly improving, error rates remain highly heterogeneous as they are affected by sequence context (for instance, homopolymer sequences) and alignment errors [ 9, 10].

Moreover, Ks is often influenced by sequence context (see papers by Laurence Hurst in 2007).

This suggests that some H3K4me3 occupation in these regions is determined not only by sequence context but also by epigenetic factors not explained by DNA sequence context.

An important caveat is that DNA polymerase behavior, reflected in measurable properties such as processivity or fidelity, is strongly influenced by sequence context.

There is increasing evidence to suggest that the various MBPs have differential DNA targets, and for the MBD and zinc finger families it appears that this could be dictated by sequence context flanking the mCpG site.

A set of rules were applied to ensure that apparent human substitutions are not simply due to alignment errors or to increased substitution rate caused by sequence context effects (see Section 2).