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Such clues can be obtained by sensitivity analysis (varying boundary conditions and parameters) and by forward modeling of the system's temporal evolution.
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The analysis was carried out by applying the generalized likelihood uncertainty estimation (GLUE) procedure when simulating laboratory measurements of freezing cylinders and by a more conventional sensitivity analysis, varying one parameter at a time, using road surface temperatures measured during nearly 1 year as upper boundary condition.
In sensitivity analysis, varying the utility values by a factor of 0.3 1.3 had little effect on the overall results.
Sensitivity analysis, varying the base-case staff time estimates by 20% and diagnostic testing costs by 60%, estimated the average cost to vary from a low of €927 per patient month to a high of €1019 per patient month.
10.7554/eLife.10559.012 Appendix figure 2. Sensitivity analysis, varying one parameter at a time.
We evaluate the influence of the slope of the sea-side boundary on the simulation results of seawater intrusion in a freshwater aquifer by employing a series of slope variations together with a sensitivity analysis by varying additional sensitive parameters (freshwater inflow and longitudinal and transverse dispersivities).
To estimate the minimal test requirements for the nanopill to be of additional benefit, trade-offs made by respondents were examined in a sensitivity analysis by varying the levels of the attributes.
To account for the uncertainty in our assumptions or to validate the robustness of our assumptions, we conducted a univariate sensitivity analysis by varying the sensitive parameters until the net cost savings faded out.
In order to deal with uncertainty generated by this issue, we also conducted a sensitivity analysis by varying the weight given to the least versus most severe levels of activity restriction and symptoms.
Likewise, we performed a two-way sensitivity analysis by varying HR.DM and f.DM (Figure 1D).
This assumption however was relaxed in the sensitivity analysis by varying λM and λB.
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CEO of Professional Science Editing for Scientists @ prosciediting.com