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However, the higher thresholds suggested by sensitivity analyses using less conservative assumptions suggest that TKR is cost-effective for all but 100 patients/year, which is unlikely to achieve sufficient savings to warrant rationing of TKR.
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If there was evidence of substantial heterogeneity, we aimed to explore possible explanations for this observed heterogeneity by performing sensitivity analyses using Review Manager 5 software.
The aim is to understand system robustness by performing sensitivity analyses using multiple parameter sets that yield reasonable model behaviour, as judged by the full cost function.
We also included several indicators designed to measure each participant's propensity to report positive change and will control for the placebo effect by conducting sensitivity analyses using these propensity to positivity scores.
Acknowledging possible deficiencies of the last-observation-carried-forward method, the robustness of the primary analysis was checked by performing two sensitivity analyses using the per-protocol and completers populations.
This was done by conducting two different sensitivity analyses using plausible assumptions to impute missing participant event data for each trial.
Finally, we calculated intraclass correlations to examine whether observed findings were potentially influenced by nesting of participants by venue, and carried out sensitivity analyses using generalized estimating equations to adjust for any effect of venue-level nesting and to calculate clustered robust standard errors for each parameter estimate.
Handling of missing data will be by complete case analysis, with sensitivity analyses using other methods including multiple imputation if possible.
When we conducted sensitivity analyses using our dataset by including only the meta-analyses that contained five or more studies, the results were also similar.
Most of the studies have done sensitivity analyses using only one dimension (like, by changing discount rate).
Our team performed structural sensitivity analyses using these two supplemental models, and drew on the T21 model in particular to assess SDG issues and targets not covered by the Randers model.
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