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Chronic widespread pain/FM is characterised by sensitisation of central pain pathways.
Where there was evidence of effect modification by sensitisation, analyses were repeated stratified by sensitisation status.
Differences in seasonal patterns by sensitisation status were assessed using generalised estimating equations.
Occupational asthma is caused by sensitisation to an agent inhaled in the workplace.
Seasonal variation in asthma was not modified by sensitisation to house dust mite or cat allergens.
In figures 2– 4, the odds of reporting asthma attacks in each bimonthly period are shown, stratified by sensitisation status.
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Circulating levels of 25(OH D are positively associated with lung function and this does not appear to be driven by allergen sensitisation or influenced by calcium levels.
As in other pain conditions, also primary headaches are accompanied by central sensitisation of pain pathways at cephalic and extra-cephalic level.
The growing awareness produced by the sensitisation process also resulted in reported behavioural change in many of the study participants, thus indicating that the method may effectively constitute an intervention in its own right.
*p < 0.05, n = 6 to 7. Thromboxane activates the RhoA/ROK pathway leading to inhibitory phosphorylation of Thr855 MYPT, the regulatory subunit of MLCP, favouring contraction by Ca2+ sensitisation [3].
Using an anti-IL-13 neutralising mAb we demonstrated that IL-13 is important for both the development and maintenance of airway pathology caused by pulmonary sensitisation to HDM.
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